The DSHARP-MIRI Treasury Program will observe molecular emission from 17 protoplanetary disks from the ALMA Disk Substructures at High Angular Resolution Project (DSHARP; Andrews et al. 2018). This program highlights what can be achieved by combining MIRI-MRS spectra with ground-based spectroscopy and imaging. MIRI-MRS provides relative abundances of key C- and O-bearing molecules, including HCN, C2H2, H2O and CO2, while ground-based high-resolution spectroscopy of CO provides emitting locations and the “denominator” for molecular abundance ratios. ALMA images provide structural information for dust beyond ~5 AU. Combined, these datasets allow for the study of volatile transport across snowlines, and in the presence of dynamical sculpting by giant planets. We will present some of the newly obtained data from the DSHARP-MIRI program and discuss implications for disk chemistry and planet formation.